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Type: |
| Karyotype |
| Organ/System: |
| Bone Marrow |
| Description: |
| BONE MARROW: Myelodysplastic syndrome (MDS), Agnogenic myeloid metaplasia, myelofibrosis, karyotype; Trisomy 8 or +8 is most common karyotype abnormality in MDS, and acute nonlymphocytic leukemias. Besa/Peter C. Nowell, M.D. Karyotype Slides
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© Slice of Life and Suzanne S. Stensaas
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Type: |
| Radiology |
| Organ/System: |
| Bone Marrow |
| Description: |
| BONE MARROW: AGNOGENIC MYELOID METAPLASIA (MYELOFIBROSIS, PRIMARY): BONE MARROW SCAN; SCAN SHOWS NO MARROW ACTIVITY EXCEPT FOR FAINT UPTAKE IN THE STERNUM. MARKED CONCENTRATIONS OCCUR IN THE LIVER AND SPLEEN WITH GREATER ACTIVITY IN THE SPLEEN. ENLARGEMENTS OF BOTH LIVER AND SPLEEN ARE NOTED, THESE FINDINGS INDICATE EXTRAM (RADIONUCLIDE SCAN)
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© Slice of Life and Suzanne S. Stensaas
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Type: |
| Radiology |
| Organ/System: |
| Bone Marrow |
| Description: |
| BONE MARROW: AGNOGENIC MYELOID METAPLASIA (MYELOFIBROSIS, PRIMARY): BONE MARROW SCAN; SCAN SHOWS NO MARROW ACTIVITY EXCEPT FOR FAINT UPTAKE IN THE STERNUM. MARKED CONCENTRATIONS OCCUR IN THE LIVER AND SPLEEN WITH GREATER ACTIVITY IN THE SPLEEN. ENLARGEMENTS OF BOTH LIVER AND SPLEEN ARE NOTED, THESE FINDINGS INDICATE EXTRAM (RADIONUCLIDE SCAN)
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© Slice of Life and Suzanne S. Stensaas
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Type: |
| Micro |
| Organ/System: |
| Skin |
| Description: |
| SKIN: SYRINGOMETAPLASIA Squamous metaplasia of the dermal portion of this eccrine duct has resulted in a jagged nest of reactive squamous epithelium (A) embedded within a fibrous dermal matrix. Upon closer inspection, small ductular lumens (B), which are important clues to this diagnosis, are evident.
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Image and description from the AFIP Atlas of Tumor Pathology
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Type: |
| Micro |
| Organ/System: |
| Skin |
| Description: |
| SKIN: SUPERNUMERARY NIPPLE (ABDOMINAL SKIN) Although there is proliferation of bundles of benign smooth muscle within the mid-dermis, the overlying epidermis shows papillary epithelial hyperplasia, and small ducts and glands are present in the underlying dermis (inset). The glands have focal apocrine metaplasia.
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Image and description from the AFIP Atlas of Tumor Pathology
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Type: |
| Micro |
| Organ/System: |
| Skin |
| Description: |
| SKIN: DERMAL NEVUS, NEUROTIZED, WITH FATTY METAPLASIA AND ANCIENT CHANGE These lesional cells show a tendency to neural differentiation with wavy elongated fibers and accumulation of eosinophilic basement membrane-like material (type 4 collagen) between the nevus cells, which are attributes of Schwannian differentiation. In addition, the involuting nevus has become infiltrated by adipocytes and some of the dermal nevus cell nuclei are hyperchromatic and irregular, a phenomenon that has been compared to "ancient change" in schwannomas.
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Image and description from the AFIP Atlas of Tumor Pathology
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Type: |
| Gross |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: COLPOPHOTOGRAPH OF THE TRANSFORMATION ZONE The boundaries of the transformation zone are the original squamocolumnar junction identified by the most peripherally located residual gland opening (small arrow) and the border between the metaplastic squamous epithelium and the endocervical glandular epithelium (large arrow). (Courtesy of Dr. Duane Townsend, Sacramento, CA.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: METAPLASTIC SQUAMOUS EPITHELIUM This figure illustrates metaplastic squamous epithelium showing prominent cytoplasmic vacuolization on the surface. In contrast to koilocytotic atypia in which nuclei are enlarged and eccentrically located (see fig. 48), the nuclei in metaplastic squamous epithelium are not enlarged and tend to be centrally located within the cell.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: IMMATURE SQUAMOUS METAPLASIA There is increased cellularity in the deep levels and increased mitotic activity (arrow) in this illustration of immature squamous metaplasia. There is retention of polarity, and the cells mature normally as they approach the surface. Chromatin is prominent, but nuclei are uniform.
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Image and description from the AFIP Atlas of Tumor Pathology
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: IMMATURE SQUAMOUS METAPLASIA WITH ATYPIA This figure shows immature squamous metaplasia with nuclear enlargement and mild atypia. So-called atypical immature metaplasia filling endocervical glands may simulate high-grade CIN. In contrast to CIN, the cells are not crowded or disorganized; the nuclei are uniform, round, and many have prominent nucleoli. The presence of mucinous epithelium overlying the metaplastic epithelium (arrows) is also helpful in distinguishing metaplasia from CIN. Mucinous epithelium rarely overlies CIN.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: TRANSITIONAL METAPLASIA Some cells have longitudinal nuclear grooves, resembling transitional epithelial cells. The lesion resembles CIN 3 because the nuclei are crowded and hyperchromatic. The lack of pleomorphism and cellular disorganization and the palisaded appearance of the basal cell layer and low mitotic activity help to distinguish this from CIN 3.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: CYSTIC MESONEPHRIC DUCT REMNANT This ampullary portion of a cystic mesonephric duct remnant has a small area of squamous metaplasia. The deep position, complex arrangement, flat to cuboidal lining cells, lack of surface connection, and absence of mucin production favor mesonephric origin.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: EPIDERMAL METAPLASIA Here the epidermal metaplasia is in the form of sebaceous glands in the cervix. This phenomenon differs from teratoma in that only skin derivatives are present in epidermal metaplasia.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Cervix, Vulva, Vagina |
| Description: |
| CERVIX, VULVA, VAGINA: SQUAMOUS METAPLASIA REPLACING ADENOSIS This squamous metaplasia is completely replacing vaginal adenosis. A small droplet of mucin (arrow) in the center of one of the squamous epithelial nests is the only vestige of mucin-secreting epithelium.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: SQUAMOUS METAPLASIA OF LACTIFEROUS DUCT Plug of keratin debris fills the orifice of a lactiferous duct. Metaplastic squamous epithelium extends into the duct. (Figures 24 and 25 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: SQUAMOUS METAPLASIA OF LACTIFEROUS DUCT Proximal extent of squamous metaplasia in duct shown in fig. 24. Note the resultant displacement of the squamocolumnar junction, mild periductal lymphocytic reaction, and beginning of duct dilatation at the lower margin of the photograph.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: INTRADUCTAL PAPILLOMA WITH SQUAMOUS METAPLASIA This low-power view shows an intraductal papilloma with prominent squamous metaplasia. The lumen of the duct containing the papilloma is visible on the left.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: MYOID METAPLASIA OF LOBULE Bundles of smooth muscle cells merging with this lobule are derived from myoepithelial cells normally present in lobular glands. Both cell types are immunoreactive for muscle common antigen in this section (HHF-35, avidin-biotin).
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: MALIGNANT CYSTOSARCOMA PHYLLODES Stromal lipocytic metaplasia resulting in a pattern of well-differentiated liposarcoma in a fibroepithelial tumor. (Figures 169 and 170 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: MEDULLARY CARCINOMA Keratin pearl formation in focal areas of squamous metaplasia. Note solid growth pattern of carcinoma cells which tend to have distinct cell borders in regions of squamous metaplasia. Intense lymphocytic reaction is present in the stroma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Gross |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: METAPLASTIC CARTILAGINOUS CARCINOMA Circumscribed contour is evident in the lower half of the specimen in this view of a bisected tumor. Margin of tumor indicated by arrows.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: METAPLASTIC CARCINOMA Well-differentiated epidermoid carcinoma and poorly differentiated adenocarcinoma merge with the spindle cell component. (Figures 305-309 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: METAPLASTIC CARCINOMA Overview of the tumor showing invasive adenocarcinoma at the upper right margin. Most of the neoplasm consisted of solid pseudosarcomatous metaplastic elements with serpiginous areas of necrosis that appear pale. (Figures 312-316 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: MATRIX PRODUCING METAPLASTIC CARCINOMA Junction between poorly differentiated carcinoma arranged in lobulated fashion around the periphery of areas exhibiting chondromyxoid metaplasia. (Figures 318 and 319 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: METAPLASTIC CARCINOMA Adenocarcinoma with transition to undifferentiated component, an intermediate step in conversion to spindle cell metaplasia. (Figures 321-324 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: RECURRENT METAPLASTIC CARCINOMA Chest wall recurrence 4 years after mastectomy for the tumor shown in figures 321 and 322. This tumor with anaplastic giant cells retains some of the spindle cell elements seen in the primary tumor. The patient had postoperative chest wall radiation and this lesion was initially interpreted as an irradiation-induced sarcoma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: LOW-GRADE ADENOSQUAMOUS CARCINOMA Intraductal carcinoma below surrounded by metaplastic fibrocollagenous neoplasm that contains small tubular elements. (Figures 328-330 are from the same patient.)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: METAPLASTIC CARCINOMA Poorly differentiated carcinoma above is immunoreactive for cytokeratin but the spindle cell pseudosarcomatous element below is unreactive (avidin-biotin, hematoxylin).
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Mammary Gland |
| Description: |
| MAMMARY GLAND: JUVENILE PAPILLOMATOSIS Part of an area of sclerosing adenosis with apocrine metaplasia of ductal epithelium adjacent to cystically dilated ducts. Hyperplastic epithelium with apocrine metaplasia fills some ducts.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: ENDOMETRIAL POLYP The glands illustrated here show endocervical-type mucinous metaplasia. The stroma is diffusely fibrotic. More typical endometrial glands were seen elsewhere in this large polyp.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: ENDOMETRIAL POLYP This polyp contains complex hyperplasia with morular metaplasia. The left side of the illustration shows a more typical endometrial polyp without hyperplasia or metaplasia.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: COMPLEX HYPERPLASIA WITH MORULAR METAPLASIA This specimen from a 28-year-old woman with clinical features of the Stein-Leventhal syndrome shows complex hyperplasia with extensive morular metaplasia. The glands around the periphery of this large focus of spindle-celled morular metaplasia lack cytologic atypia and are separated by at least thin wisps of residual endometrial stroma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: ENDOMETRIOID ADENOCARCINOMA WITH SQUAMOUS DIFFERENTIATION This well-differentiated adenocarcinoma contains large foci of benign-appearing squamous epithelium (adenocarcinoma with squamous metaplasia or adenoacanthoma).
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: ENDOMETRIOID ADENOCARCINOMA WITH SQUAMOUS DIFFERENTIATION This morule from the case illustrated in figure 80 is surrounded by malignant but well-differentiated glands. The cells of the morule do not show keratinization or intracellular bridges but do demonstrate sheet-like growth, eosinophilic and glassy cytoplasm, and a decreased nuclear/cytoplasmic ratio compared with the immediately adjacent glandular cells. Most of them are spindle shaped. This tumor may be designated adenocarcinoma with squamous or morular metaplasia or adenoacanthoma, but most importantly, the glandular component is well differentiated or grade I.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: ADENOSARCOMA The cellular stroma of this tumor forms hypercellular cuffs surrounding the benign-appearing, mostly slit-like glands. Foci of squamous metaplasia are present.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: ADENOSARCOMA A large focus of well-differentiated chondrosarcoma is present in this example. Also note foci of squamous metaplasia and of hypercellular stromal cuffs around the glandular component.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: METAPLASTIC CARCINOMA OF THE ENDOMETRIUM In this illustration, the cells of the adenocarcinoma gradually merge with a malignant stromal component (sarcomatoid carcinoma) rather than showing a sharp transition, as in carcinosarcoma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: CARCINOSARCOMA This illustration compares a focus of chondrosarcoma (left) with one of squamous metaplasia (right). The chondrosarcoma cells have a more glassy cytoplasm, less prominent cell membranes, and a more lacunar appearance.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: SQUAMOUS METAPLASIA OF THE ENDOMETRIUM Benign squamous metaplasia appears on the surface of the endometrium in this curettage specimen, with some acute and chronic inflammatory cells in the underlying stroma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: MUCINOUS METAPLASIA OF THE ENDOMETRIUM In this illustration, endometrial glands show intracytoplasmic and intraluminal mucin, bland nuclei, and separation by endometrial stroma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: MUCINOUS METAPLASIA OF THE ENDOMETRIUM Small glands resembling benign endocervical glands are separated by endometrial stroma. Without this stroma, it might be postulated that a fragment of endocervix had been included in this endometrial curettage specimen.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: BONY SPICULES IN THE ENDOMETRIUM These fragments of bone, which were evident on gross examination, occurred in a 17-year-old girl with endometritis and a tubo-ovarian abscess but no known history of pregnancy. The mature bone (at the top of the photomicrograph) is separated from the endometrium (at the bottom) by blood. The bone may be of either fetal or metaplastic origin.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: OSSEOUS METAPLASIA OF THE ENDOMETRIUM Numerous foci of benign-appearing osseous and cartilaginous metaplasia occurred in this hyperplastic endometrium from a 30-year-old infertile woman. Nuclear atypia is absent, and the osseous tissue appears to arise from endometrial stroma. (Figures 258 and 259 are from the same patient)
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Micro |
| Organ/System: |
| Uterine Corpus |
| Description: |
| UTERINE CORPUS: CARTILAGINOUS METAPLASIA OF THE ENDOMETRIUM This photomicrograph shows a focus of benign cartilaginous tissue arising from endometrial stroma. There is no associated neoplasm, although the patient subsequently developed a focal, well-differentiated endometrioid adenocarcinoma that retained foci of osseous and cartilaginous metaplasia in its stroma.
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Image and description from the AFIP Atlas of Tumor Pathology
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|  |
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Type: |
| Gross |
| Organ/System: |
| Thyroid Gland |
| Description: |
| THYROID GLAND: FOLLICULAR ADENOMA WITH EXTENSIVE CARTILAGINOUS METAPLASIA ("ADENOCHONDROMA") The lobular configuration and shiny white appearance of the cartilaginous element in this tumor is evident. (Courtesy of Dr. Maurizio Pea, Vicenza, Italy.)
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