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Type:   Micro Organ/System:   Heart Description:   HEART: Myofiber Atrophy: Micro H&E high mag good demonstration of myofiber atrophy from case of ischemic heart disease © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Myofiber Atrophy: Micro H&E high mag good demonstration of atrophic myofibers from case of ischemic heart disease © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Myofiber Atrophy: Micro H&E high mag excellent demonstration of atrophic myofibers from case of ischemic heart disease © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Chronic Ischemia: Micro H&E med mag subendocardial band of muscle that usually shows myocytolysis shows marked atrophy and loss of muscle fibers subendocardial myocardium is necrotic good chronic ischemia lesion © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Oral Description:   ORAL: Pharynx: Radiation: Micro H&E med mag chronic radiation injury with few atrophic muscle cells thickened artery fibrosis and atypical fibroblastic cell © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Hypertrophy: Micro H&E high mag excellent example myofiber atrophy presumably following hypertrophy and also involving ischemia © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Cardiomyopathy: Micro trichrome hypertrophied fibers with perinuclear clear zone could be atrophic © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Cardiomyopathy: Micro trichrome high mag bizarre vacuolated myofibers atrophic change and fiber disarray with replacement fibrosis good example © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Heart Description:   HEART: Cardiomyopathy: Gross ventricular slices hypertrophy and extensive myocardial fibrosis a unique case of global fiber disarray with atrophy and fibrosis © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Heart Description:   HEART: Cardiomyopathy: Gross excellent ventricular slice with hypertrophy and fibrosis a unique case of global fiber disarray with hypertrophy then atrophy and then fibrosis slide 2 same case © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Hepatitis: Gross good example of subacute red atrophy close-up view © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Hepatitis: Gross two slices of liver with classical acute red atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro plastic section high mag loss of myofilaments © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro plastic section high mag loss of myofilaments © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro plastic section high mag loss of myofilaments © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro H&E med mag this slide is to illustrate that atrophy cannot be detected with ordinary paraffin sections see plastic section 663 © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro retic stain med mag reticulin appears increased over that seen in a normal heart © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro H&E Duchenne muscular dystrophy with death due to heart failure little can be seen with this type of section much too thick does show hypertrophy however same as plastic section 6 © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro retic stain high mag Duchenne muscular dystrophy basement membranes appear thicker than normal as would be expected with atrophy same as plastic sections 6 © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Normal: Micro retic stain this is taken at the same mag as the illustrations of atrophy and is to show the normal amount of reticulin © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Amyloidosis: Micro H&E high mag marked atrophy of liver cells with hyaline appearing amyloid in interstitial spaces a very good example © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Amyloidosis: Micro H&E high mag excellent interstitial amyloid myofiber atrophy is not really evident but then is rarely is with paraffin sections this is a good example of the disease © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Oral Description:   ORAL: Tongue: Amyloidosis: Micro H&E high mag excellent illustration of skeletal muscle atrophy with interstitial amyloid © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Thyroid: Lymphocytic Thyroiditis: Micro H&E med mag fair to good example with some good follicles and atrophic ones with surrounding lymphocytes © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Compensatory Hypertrophy: Gross good example with opposite atrophic kidney apparently due to ureteral obstruction fine calculi in pelvis of hypertrophied kidney © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Cyclosporin Toxicity: Micro trichrome low mag excellent example interstitial fibrosis and tubular atrophy secondary to cyclosporin © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Cyclosporin Toxicity: Micro trichrome very low mag excellent example of interstitial fibrosis and tubular atrophy secondary to cyclosporin © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Steroid Atrophy: High mag H&E excellent atrophy due to steroid therapy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Steroid Atrophy: High mag H&E excellent atrophy secondary to steroid therapy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Steroid Atrophy: High mag H&E excellent steroid induced atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Steroid Atrophy: High mag H&E excellent steroid induced atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   EM Organ/System:   Heart Description:   HEART: Atrophy: Electron micrograph demonstrating excessive number mitochondria especially about nucleus early atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   EM Organ/System:   Heart Description:   HEART: Atrophy: Electron micrograph demonstrating advanced myofiber atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   EM Organ/System:   Heart Description:   HEART: Atrophy: Electron micrograph © University of Alabama at Birmingham, Department of Pathology

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Type:   EM Organ/System:   Heart Description:   HEART: Atrophy: Electron micrograph demonstrating marked fiber atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   EM Organ/System:   Heart Description:   HEART: Atrophy: Electron micrographs demonstrating fiber does not connect with another fiber other frame shows dilated sarcoplasmic reticulum © University of Alabama at Birmingham, Department of Pathology

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Type:   EM Organ/System:   Heart Description:   HEART: Atrophy: Electron micrographs demonstrating marked loss of myofibrils in fiber and inset with dilated sarcoplasmic reticulum © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Hydronephrosis: Gross good example for dilated ureter and pelvis and parenchyma atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Extremeties Description:   EXTREMETIES: Hand: Muscle Atrophy: Gross good example of muscle atrophy said to be due to syringomyelia © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Extremeties Description:   EXTREMETIES: Hand: Muscle Atrophy: Gross close-up excellent example of interosseous muscle atrophy said to be due to syringomyelus © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy: Micro high mag H&E excellent example from a transplant case © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Normal Myofiber: Hypertrophy atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Thyroid: Lymphocytic Thyroiditis: Micro high mag H&E nice illustration of small atrophic appearing follicles infiltrated with lymphocytes © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Thyroid: Lymphocytic Thyroiditis: Micro high mag H&E very good atrophic follicle with lymphocytic infiltrate © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Thyroid: Lymphocytic Thyroiditis: Micro high mag H&E excellent view of lymphocytes infiltrating atrophic follicle best I have seen to this date © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Arteriosclerosis: Gross aorta with well shown renal artery containing large plaque and kidney with multiple cortical scars and atrophy also abdominal aorta aneurysm with mural thrombus excellent for renovascular hypertension © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Global Ischemia: Gross coronal section showing marked cortical necrosis and atrophy and necrosis in basal ganglia caused by cardiac arrest © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Global Ischemia: Gross coronal section with well shown cortical atrophy and necrosis and basal ganglia necrosis caused by cardiac arrest © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Diabetic Cardiomyopathy: Micro med mag H&E mid-mural myocardium with hypertrophy and interstitial fibrosis atrophy is present marked increase in interstitial fibroblastic cells © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Diabetic Cardiomyopathy: Micro med mag H&E myofiber hypertrophy some atrophy interstitial fibrosis with many fibroblastic cells © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Diabetic Cardiomyopathy: Micro high mag H&E hypertrophied fibers with some evidence of atrophy and marked interstitial fibrosis with many fibroblastic type cells © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Pontine Infarct: Gross fixed tissue cross sections of pons and stem at olives left anterior cystic lesion on anterior pons with evidence of tract atrophy in olive section three year old lesion by history in 36 year old type 1 diabetic © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Diabetic Cardiomyopathy: Micro high mag H&E mid mural left ventricle fiber hypertrophy with atrophy and interstitial fibrosis with many fibroblastic cells © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Heart Description:   HEART: Diabetic Cardiomyopathy: Micro high mag H&E myofiber hypertrophy and atrophy with marked interstitial fibrosis and many fibroblastic cells © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cerebral Cortical Atrophy: Gross fixed tissue close-up view vertex with meninges removed excellent example of severe atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cerebral Cortical Atrophy: Gross fixed tissue vertex view meninges intact severe cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Atrophy: Micro high mag H&E excellent example © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Body Description:   BODY: Cachexia: Gross good example tastefully shown with face out of picture and genitalia covered muscle atrophy is striking © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Endocrine Description:   ENDOCRINE: Adrenal: Atrophy: Gross fixed tissue close-up of very small adrenal case of vacant sella © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Alzheimers Disease: Gross fixed tissue coronal sections with marked cortical atrophy and dilated ventricles © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy And Focal Meningeal Calcification: Gross view of parietal lobe primarily with marked atrophy and clearly evident opaque white plaques © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy And Focal Meningeal Calcification: Gross fixed tissue close-up view showing marked cortical atrophy and focal white plaques of calcium © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Sudanophilic Leukodystrophy: Gross fixed tissue external view of cortex with meninges removed showing cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Sudanophilic Leukodystrophy: Gross fixed tissue sections through peduncles showing marked long tract atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Atrophy: Micro high mag H&E good depiction focal fiber atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Adrenal: Amyloidosis: Micro high mag H&E well shown interstitial amyloid with cellular atrophy not the best exposure but easily seen © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Progressive Systemic Sclerosis: Micro med mag H&E some tubular atrophy with interstitial fibrosis and onion skin thickening of small arteries quite good © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Muscle-Soft tissue Description:   MUSCLE-SOFT TISSUE: Skeletal muscle: Atrophy: Micro low mag H&E marked neurological atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue view of cerebral hemispheres from vertex cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue view of base of brain showing cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue coronal section cerebral hemispheres cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue coronal section cerebral hemispheres cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue cerebral hemispheres cortical atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue close-up view of cortex showing atrophy and white matter showing substance loss © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Globoid Leukodystrophy: Gross fixed tissue coronal section cerebral hemispheres cortical atrophy and subcortical leukomalacia © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Adrenal: Atrophy: Micro low mag H&E atrophy secondary to corticoid therapy © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Breast Description:   BREAST: Atrophy: Micro low mag H&E atrophic lobules and normal connective tissue © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Breast Description:   BREAST: Atrophy: Micro low mag H&E normal duct in postmenopausal woman © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Blood-RES Description:   BLOOD-RES: Thymus: Lymphoid Atrophy In Newborn: Micro low mag H&E typical atrophy associated with infection in newborn © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cerebellum Folia Atrophy: Gross fixed tissue case of AIDS with alcoholic hepatitis see caption to slide © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Endocrine Description:   ENDOCRINE: Thyroid: Atrophy Secondary To Pituitectomy: Gross natural color close-up of small gland type I diabetic 9yrs postoperative pituitectomy for retinal lesions © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Endocrine Description:   ENDOCRINE: Adrenal: Atrophy Secondary To Pituitectomy: Micro low mag H&E rather good example of atrophy case of type I diabetes with pituitectomy for nine years for retinal lesions © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy: Gross fixed tissue frontal poles I think shown close-up with marked cortical atrophy good photo © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy: Gross fixed tissue coronal section hemispheres showing marked cortical atrophy especially in temporal lobes and ventricular dilation 79yo man with body burns © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cerebellar Vermis Atrophy Probably Due To Alcoholism: Gross fixed tissue horizontal section of pons and cerebellum showing vermis atrophy better than any photo I have see to date © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Urinary tract Description:   URINARY TRACT: Kidney: Progressive Systemic Sclerosis: Micro low mag H&E nice photo showing tubular atrophy and diffuse interstitial fibrosis with sclerotic glomeruli and ones with mesangial fibrosis not diagnostic © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy Frontal Lobes: Gross fixed tissue head on view © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Frontal Lobe Atrophy: Gross fixed tissue anterior view of hemispheres with leptomeninges removed shows gyral atrophy very well © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Alzheimers Disease: Gross fixed tissue direct anterior view of frontal lobes with atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Alzheimers Disease: Gross fixed tissue coronal section cerebral hemispheres with moderate ventricular dilation and hippocampal atrophy © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Infarcts Multiple Remote: Gross fixed tissue horizontal section cortical atrophy and many old infarcts © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy And Hydrocephalus: Gross fixed tissue coronal section cerebral hemispheres severe changes consistent with Alzheimers disease © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Cortical Atrophy And Hydrocephalus: Gross fixed tissue coronal section cerebral hemispheres changes consistent with Alzheimers disease © University of Alabama at Birmingham, Department of Pathology

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Type:   Gross Organ/System:   Nervous system Description:   NERVOUS SYSTEM: Brain: Binswangers Subcortical Encephalopathy: Gross fixed tissue lateral view of left cerebral hemisphere showing quite well rather marked cortical atrophy © University of Alabama at Birmingham, Department of Pathology