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Type:   Micro Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Hepatitis B: High mag H&E apoptosis proved case of chronic active hepatitis © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Hepatitis B: High mag H&E apoptosis proved case of chronic active hepatitis © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Hepatitis B: High mag H&E apoptosis proved case chronic active hepatitis © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Liver-Biliary Description:   LIVER-BILIARY: Apoptosis: Micro high mag H&E the eosinophilic body in this slide appears to be an example of cell necrosis by the apoptosis mechanism it otherwise has been called a Councilman body see other slides under this disease diagnosis © University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Apoptosis in prostate after orchiectomy © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Prostate, apoptosis TUNEL stain © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Micro Organ/System:   Male Reproductive Description:   MALE REPRODUCTIVE: Prostate, apoptosis TUNEL stain © Dr. Peter Anderson, University of Alabama at Birmingham, Department of Pathology

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Type:   Karyotype Organ/System:   Bone Marrow Description:   BONE MARROW: Philadelphia chromosome in Chronic Myelogenous Leukemia (CML); Ph, t(9;22) results in a fusion mRNA of 210 kd called bcr/abl which inhibits cellular apoptosis and increase granulocytes in Chronic Myelogenous Leukemia (CML). Besa/Peter C. Nowell, M.D. Karyotype Slides © Slice of Life and Suzanne S. Stensaas

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Type:   Karyotype Organ/System:   Lymph Node Description:   LYMPH NODE: Evolved B cell NonHodgkin's lymphoma, NHL; t(8;14) and t(14;18), appears in 75% of follicular NHL, juxtaposing the bcl-2 (band 18q21) proto-oncogene with Ig (band 14q32) heavy chain gene (resulting in deregulation of bcl-2 (inhibits apoptosis). Besa/Peter C. Nowell, M.D. Karyotype © Slice of Life and Suzanne S. Stensaas

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Type:   Micro Organ/System:   Skin Description:   SKIN: GLOBOID BODIES IN SPITZ NEVUS The pink eosinophilic globoid Kamino bodies in this Spitz nevus are probably apoptotic (dying) lesional cells. Image and description from the AFIP Atlas of Tumor Pathology

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Type:   Micro Organ/System:   Lymph Nodes-Spleen Description:   LYMPH NODES-SPLEEN: SECONDARY FOLLICLE The bcl-2 protein, which blocks programmed cell death (apoptosis), is strongly expressed on the mantle B lymphocytes and adjacent T lymphocytes but expressed on few cells in the germinal center. Image and description from the AFIP Atlas of Tumor Pathology

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Type:   Micro Organ/System:   Lymph Nodes-Spleen Description:   LYMPH NODES-SPLEEN: DIFFUSE LARGE B-CELL LYMPHOMA WITH PROMINENT KARYORRHEXIS Many apoptotic bodies are present in this large cell lymphoma. Image and description from the AFIP Atlas of Tumor Pathology

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Type:   Micro Organ/System:   Lymph Nodes-Spleen Description:   LYMPH NODES-SPLEEN: EPSTEIN-BARR VIRUS-ASSOCIATED INFECTIOUS MONONUCLEOSIS A heterogeneous population is present, including cells mimicking Hodgkin cells. However, the spectrum of cell types and the extensive apoptosis present would not be found in Hodgkin's disease. Image and description from the AFIP Atlas of Tumor Pathology